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The target of this investigation was to model and optimize selected process parameters when extracting oil from Garcinia kola. Artificial neural network (ANN) and Box-Behnken design (BBD) in response surface methodology (RSM) were used for the modelling and optimization of the process parameters. The optimized process values were 397.86 mL and 399.99 mL for solvent volume; 109.32 min and 107.55 min for extraction time; 72.64 g and 70 g for sample mass and maximum yields of 20.839 wt% and 20.488 wt% for RSM and ANN respectively. The highly positively correlated experimental and anticipated values validated the models.